Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat

S Ma; A Blasiak; FE Olucha-Bordonau; AJM Verberne; AL Gundlach

Journal article

Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat

S Ma, A Blasiak, FE Olucha-Bordonau, AJM Verberne, AL Gundlach

Journal of Physiology | WILEY | Published : 2013

DOI: 10.1113/jphysiol.2013.254300

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Abstract

Abstract The nucleus incertus (NI) of the rat hindbrain is a putative node in the ascending control of the septohippocampal system and hippocampal theta rhythm and is stress and arousal responsive. NI contains GABA neurons that express multiple neuropeptides, including relaxin-3 (RLN3) and neuropeptide receptors, including corticotrophin-releasing factor receptor-1 (CRF-R1), but the precise anatomical and physiological characteristics of NI neurons are unclear. Therefore, we examined the firing properties of NI neurons and their responses to CRF, the correlation of these responses with occurrence of relaxin-3, and NI neuron morphology in the rat. Most NI neurons excited by intracerebroventri..

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Andrew Gundlach Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by Polish Ministry of Science and Higher Education

Awarded by The Ministry of Health, Spain

Funding Acknowledgements

This work was supported by research grants from the National Health and Medical Research Council (NHMRC) of Australia (520299 to S. M.; 277609, 509246 and 1005988 to A. L. G.; 350207 to A.J.M.V.; a research grant from the Polish Ministry of Science and Higher Education N N303 569939 (to A. B. and A. L. G.); a Commonwealth of Australia Endeavour Research Fellowship (to A. B.); a grant from the Florey Neuroscience Institutes Foundation (to S. M. and A. L. G.); research grants from the National Heart Foundation of Australia and Austin Hospital Foundation (to A.J.M.V.); a research grant from The Ministry of Health, Spain (ISCIII-FIS PI061816 to F.E.O.); a collaborative research grant from Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, USA (to A. L. G.); a grant from the Besen Family Foundation and the Pratt Foundation (to A. L. G.); and by the Victorian Government Operational Infrastructure Support Program. S. M. was the recipient of an NHMRC (Australia) Biomedical Postdoctoral Fellowship. A. L. G. is an NHMRC (Australia) Senior Research Fellow.